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One-Stop Solution for
Antibody Libraries & Characterization
At the forefront of genetic engineering, Ranomics excels in antibody discovery services, utilizing cutting-edge techniques like yeast and mammalian display to identify and isolate novel antibodies. Our commitment to innovation and precision is manifested in comprehensive one-pot solutions for epitope mapping, affinity maturation, mutagenesis libraries, and high-throughput binding studies.
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Starting with the parental antibody's native sequence, Ranomics' VariantFind library building technology produces diverse antibody libraries with high specificity and control. Antibody libraries are transformed into and displayed on the surface of yeast cells or mammalian cells, followed by cycles of panning for antigen protein.
By conjugating soluble antigen proteins to fluorescence markers, Ranomics can rapidly isolate and identify high-affinity antibody-antigen interactions using fluorescence-activated cell sorting (FACS) and next-generation sequencing (NGS).
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" We recently performed specific mutagenesis of all six CDRs in a single scFv antibody sequence with Ranomics. We were very pleased with the mutation diversity that was obtained and were impressed with how specific (and fast) the mutations could be introduced to make a new library. "
- Adam Adler, Ph.D, Chief Scientific Officer, GigaGEN
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Our Services
Therapeutic Antibody Development
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Cell display services
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Antibody Affinity Maturation by yeast and mammalian display
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Antibody Epitope Mapping
Antibody Variant Libraries
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Designing and constructing high-diversity synthetic antibody libraries.
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Immune repertoire sequencing and next-generation sequencing (NGS) analysis
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Combinatorial, site-saturation, scanning libraries
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Protein Expression
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Protein expression in various expression systems: Mammalian cell, Yeast cells, E.coli, B.subtilis
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Ultra-high-throughput protein expression screening
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Cell-line/ strain development
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Functional Assays
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Flow cytometry analysis
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Flow cytometry cell sorting (FACS)
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Fluorescence measurement plate reader
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Custom Assay Development
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Protein Stability Engineering - site-saturation library or combinatorial library + cell display assay
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Functional Data generation (AI-targeting) - Scanning SSL - any cell biology experiment - functional assay -deep sequencing.
Case studies
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Technologies
Identifying Optimal Antibody Fragments For CAR-T therapy
Ranomics utilizes a comprehensive approach that merges proficiency in antibody engineering, high-throughput screening, and bioinformatics analysis to to rapidly identify the most effective antibody fragments for CAR-T therapy
Schedule Free Antibody Engineering Consultation
Request a personalized antibody engineering consultation meeting today, and let our experts guide you towards tailored solutions for your research or therapeutic development.