High-throughput Functional Studies for Variant Classification

Ranomics provides datasets generated from high-throughput functional studies. We classify all variants, including Variants of Unknown Significance (VUS), through our experimental assays and statistical pipeline. Our datasets are used by clinical labs to evaluate a patient's risk of developing hereditary diseases.



A smart query interface with VCF support to access functional experimental data for the variant(s) in question.

Ranomics API

A developer-friendly API for variant interpretation software companies to integrate our functional experimental data to enhance their existing pipeline.


BRCA1 is a tumour suppressor protein with a critical role in maintaining genomic stability. Mutations in the BRCA1 gene account for approximately 40% of hereditary breast cancers and over 80% of hereditary breast and ovarian cancers.
Read our Product Overview
TP53 is a tumour suppressor protein which regulates the transcription of genes involved in cell cycle regulation, apoptosis, senescence and DNA damage response. Somatic mutations in the TP53 gene are highly prevalent in human cancers, observed in approximately 50% of cancers. Additionally, germline mutations have been observed in approximately 70% of patients with Li-Fraumeni Syndrome, an inherited heterogeneous cancer predisposition disorder.
CHEK2 is a tumour suppressor protein which regulates cell cycle progression and the DNA damage checkpoint. Mutations in the CHEK2 gene are associated with an elevated risk of cancer, including breast and colorectal cancers.
CDK4 is a tumor suppressor gene that regulates cell cycle progression. Heterozygous pathogenic mutations in the CDK4 gene are associated with familial cutaneous malignant melanoma.


Wet-lab Experimental Pipeline

Ranomics has a high-throughput pipeline for generating functional experimental data. Our experimental pipeline involves two major procedures: (1) The generation of all single missense variants of a human disease gene, and (2) Expression of the genetic variants in a disease model system to determine a loss or gain of function for each variant.

Data analytics and statistical modelling

Ranomics catalogues the functionality of each genetic variant in our experimental assays. All datasets are benchmarked using validated clinical patient data, which ensures for high clinical sensitivity and specificity.

Software application for genetic variant queries

Ranomics has an accessible database for clinical laboratories to query genetic variants. Users will receive a variant report documenting the “functional score” and pathogenic/benign classification of the variant.


Interactive Bio Software
Beijing Genomics Institute
Global Alliance for Genomics and Health
Veritas Genetics
Indie Bio

MaRS Centre – West Tower
661 University Ave., Suite 1300
Toronto, Ontario, Canada
M5G 1M1

internal secret white paper