The Engine of Discovery: Our Integrated Technology Platforms

The Protein Engineering Engine: Designing Better Molecules

Our protein engineering engine is built to explore vast design landscapes and isolate variants with transformative properties.

Discovery & Diversity Generation

Technology: Custom Library Synthesis

We employ iterative cycles of mutagenesis and selection to mimic natural evolution on an accelerated timescale. Our strength lies in creating massive combinatorial, site-saturation or deep mutational scanning libraries (e.g., NNK, trinucleotide) that provide an unparalleled starting pool of genetic diversity, dramatically increasing the probability of discovering novel functionality.

High-throughput Screening & Selection

Technologies: Yeast & Mammalian Display | Deep Mutational Scanning

We utilize advanced display platforms to screen libraries of billions of variants. By linking genotype to phenotype on the cell surface, we can rapidly isolate rare candidates with desired characteristics. Deep mutational scanning provides comprehensive, base-by-base functional maps, generating rich datasets that guide intelligent library design and inform AI models.

Technologies: Yeast & Mammalian Display | Recombinant Protein Expression

For biologics development, we have a dedicated workflow for affinity maturation. Using targeted mutagenesis and stringent selection pressures, we can increase binding affinity by orders of magnitude, delivering therapeutic and diagnostic candidates with exceptional potency and specificity.

Optimization & Affinity Maturation

The Cell Engineering Engine: Building Better Systems

Our cell engineering engine provides the precision and robustness needed to create reliable biological systems for research, assay development, and therapeutics

Precision Genome Editing

Technology: CRISPR/Cas9 Gene Editing

We utilize CRISPR-based editing for conductiong efficient gene knockouts to the design and insertion of complex, multi-operon knock-in vehicles. Our expertise allows us to perform difficult edits in a wide range of host organisms, providing you with the exact genetic modifications your project requires

Mammalian System Construction

Technology: Stable Cell Line Development

We create high-performance stable mammalian cell lines (e.g., CHO, HEK293) for consistent, long-term protein production or assay execution. Our rigorous development and clonal selection process ensures monoclonality and stability, providing you with a reliable and scalable cellular asset for biologics manufacturing or cell-based screening.

Technolgy: Yeast & Bacterial Genome Engineering

We specialize in the high-precision engineering of microbial systems, including E. coli, S. cerevisiae, and P. pastoris. Our platform focuses on optimizing metabolic pathways, constructing novel synthetic circuits, and maximizing protein expression titers. Whether for producing small molecules or high-yield recombinant proteins, we deliver robust, production-ready microbial strains tailored to your industrial and research needs.

Microbial Engineering & Strain Development

The Functional Validation Platform: Ensuring Performance with Precision

An engineered product is only as good as its performance. This platform bridges our engineering engines, providing the critical, multi-parametric data to validate function at every stage of a project. We design and execute custom assays to ensure every result is biologically meaningful and directly relevant to your end goals

Genotypic & Library Validation

Technology: Next-Generation Sequencing (NGS) Assays

We go to the sequence level to guarantee precision and quality. Our NGS platform is used to confirm the accuracy of every CRISPR-mediated edit, perform comprehensive off-target analysis, and verify the diversity and quality of our vast combinatorial libraries. For deep mutational scanning and other pooled screens, NGS is the core engine we use to decode the results, delivering rich, quantitative functional landscapes.

Biochemical & Functional Characterization

Technology: Enzyme Assays and Protein-protein Interaction Assays

We directly measure the functional output of your engineered proteins. Our team develops bespoke enzyme or binding assays to characterize and screen for improvements in catalytic activity and substrate specificity. For antibodies and other biologics, we employ a suite of in vitro and cell based binding assays to precisely quantify affinity and epitope specificity

Technology: Flow Cytometry | Cell-based Functional Assays

We analyze function in the most relevant context: the cell. Our flow cytometry platform, with multi-color capabilities, is essential for the high-throughput screening and selection steps in our yeast and mammalian display workflows. It's also critical for validating our cell engineering, such as confirming CAR expression on T-cells or verifying knockout of a surface marker. We complement this with a range of cell-based assays, including reporter gene, cell viability, and signaling pathway readouts, to confirm your engineered product performs as intended within a complex biological system.

Cellular & Phenotypic Analysis

Customer reviews

Discover what our clients think about our service

We recently performed specific mutagenesis of all six CDRs in a single scFv antibody sequence with Ranomics. We were very pleased with the mutation diversity that was obtained and were impressed with how specific (and fast) the mutations could be introduced to make a new library.

Adam Adler, Ph.D - Grifols

We are very pleased with the diversity and specific composition of the synthetic variant libraries produced by Ranomics. Our projects were executed on time or ahead of schedule and throughout the process Leo and Jonathan were always available to answer any questions we had. Working with the Ranomics team has been a pleasure ”

Mara Inniss, Ph.D - Obsidian Therapeutics

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Let's Solve Your Scientific Challenge

Your most ambitious research goals are within reach. We excel at tackling the complex protein and cell engineering challenges that stand in the way of discovery. Use the form below to provide some initial details about your project. All submissions are treated with complete confidentiality and will be reviewed by our technical team.

What Happens Next?

1. Submission: Your inquiry is securely received.

2. Scientific Review: A member of our scientific staff evaluates your project needs.

3. Consultation: We will contact you within 1-2 business days to schedule a confidential, no-obligation scoping call.